Vani Subramaniyam (Jyothika), her best friend Radhika (Sharbani Mukherjee) and their friends are pranksters in a ladies' college. Like other college girls, they sing songs, break rules and wreak havoc. They also have a grudge against Gita (Ishita Arun), another girl from the college.
Lakshmi, Radhika's aunt, wants her niece to get married. To escape, Vani and Radhika fake a boyfriend whose name is Ramesh. However, this fantasy takes on a whole new meaning when a person named Ramesh calls and sends Radhika letters claiming to be her boyfriend. To end this nuisance, Vani and Radhika invite Ramesh to the hostel during the college dance program. Vani instructs Radhika to bring a gun for their safety.
Mysteriously, without them shooting him, Ramesh (Major Ravi) dies. At the same time, Radhika loses her chain. Suspicion eventually falls on the two friends. Gayathri (Tabu) is a man-hating police officer, and is put on the case. To make matters worse, Gita suddenly disappears. Vani and Radhika find themselves as fugitives, running from the law in a bid to prove their innocence. Meanwhile, the real killer is still on the loose.