Detective Sherlock Holmes and his stalwart partner Watson engage in a battle of wits and brawn with a nemesis whose plot is a threat to all of England.
Robert Maillet (Dredger) accidentally knocked out Robert Downey Jr. (Sherlock Holmes) while shooting a fight scene.
In an attempt to escape the clutches of wearing a tight corset every morning, Rachel McAdams would trick the costumers by pushing her stomach out or eating a big breakfast of oatmeal before being laced up. However, they eventually caught on to her ruse.
Watson's line to Holmes, "You know that what you're drinking is for eye surgery?", is an obscure reference to Holmes' cocaine usage. At the time, cocaine was used as a topical anesthetic for eye surgery. Holmes injects cocaine in the stories.
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