This contemporary adult comedy traces the twists and turns in the lives of Sid (Riteish Deshmukh) and Adi (Tusshar Kapoor), who are roommates and good friends. Adi is a struggling actor, whilst Sid is a struggling DJ who admires his own dog, Sackru more than himself.
Adi falls in love with Simran (Neha Sharma) who works at a call-center, and Sid falls for Anu (Sarah Jane Dias) whom he meets at a fashion show. Then Anu and Simran go to Goa to meet Anu's father, Marlo (Anupam Kher) who has lost his mental stability ever since the death of his mother.
In Goa, Baba 3G (Chunky Pandey), a conman posing as a priest tells Marlo that his dead mother has been reincarnated into a female dog. When Adi and Sid take Sackru and follow the girls to Goa and meet Marlo, Sackru copulates with the female dog. Marlo then believes the dog is not his mother as she was so pure and didn't let her husband touch her.
However, Baba 3G, not wanting to lose his business, tells Marlo that his father has been reincarnated as Sackru, and Sackru is then kidnapped by Marlo. How will the ensuing mayhem be resolved?