'Adhurs' is about two twin brothers who get separated at birth. Narasimha (NTR) gets raised by a single mother and he becomes a top police officer, who goes undercover for an important assignment.
Chari (NTR) is brought up by a family of traditional Hindu priests. A gang of criminals (Asish Vidyardhi and Mahesh Manjrekar) are desperately trying to expose the location of a noted scientist and his family.
The rest of the story is about the relationship between the scientist and the twins and the comedy generated when Narasimha and Chari are forced to switch roles and impersonate each other.